Evaluation of Anti-Depressant Property of Hibiscus rosasinensis Plant Extracts

Author(s): Markapudi Sucharitha and Manda Nagamani*

Abstract: Aim: Flowers of Hibiscus rosa-sinensis Linn (Malvaceae) popularly known as “China-rose flowers” contain flavonoids. Flavonoids have been found to have antidepressant activity. The research work is concentrated about the extractions, phytochemical investigation and biological evolution of the antidepressant activity of Hibiscus Rosa sinensis in the experimental animal (mice) model i.e., forced swimming test tail suspension test and sleep induced test in the mice respectively. Methods: Anti-Depressant activity of ethyl acetate extract containing Hibiscus Rosa sinensis flower and leaf evaluated in(30 and 200mg/kg),tail suspension test (30 and 60mg/kg), forced swim test and (30 and 200mg/kg) mice as compared to vehicle control. Results: The tail suspension and forced swimming tests, sleep induced method three behavioral testes in rodent that predicted the clinical efficacy of many new types of antidepressant medication. Hibiscus rosasinensis extracts consists of this are the constituents are responsible for controlling the oxidation. The extract at oral doses 100 and 200 mg/kg for 14 days significantly P≤0.01 decreased the duration of immobility as dose-dependent manner in the forced swim test, sleep induced method and tail suspension test in the mice. Conclusion The finding of the present investigation suggests that antidepressant-like effect of H. rosa-sinensis is mediated through dopaminergic, adrenergic, and serotonergic mechanisms. In our further study, we will try to explore selective mechanism of action of H. rosa-sinensis flowers responsible for antidepressant-like activity

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