Acute Toxicity Study in Rat for Hydroalcoholic Extract of Combination Containing Butea monosperma, Flemingia strobilifera and Moringa oleifera (Research Article)

Author(s): Shital Devlekar*, Jignyasha Raval and Anubha Khale

Abstract: The general perception that herbal remedies or drugs are safe and devoid of adverse effects is not only untrue, but also misleading. Herbs have been shown to be capable of producing a wide range of side effects or adverse reactions, undesirable drug interaction causing serious injuries, life-threatening conditions and even death [6]. This has created a major concern about safety of plant extracts to both national health authorities and the general public [11,30] which calls for a need to further investigate the safety profile of plants and their extracts [28]. Acute toxicity study provides an estimate of the intrinsic toxicity of the substance, expressed as an appropriate lethal dose (e.g., LD50). Acute oral toxicity study is thus vitally needed not only to identify the range of doses that could be used subsequently, but also to reveal the possible clinical signs elicited by the substances under investigation [22]. In the present research work, the acute oral toxicity study was carried out on female rats, to check the safety of the standardized hydroalcoholic extracts of combination containing Butea monosperma, Flemingia strobilifera and Moringa oleifera as per OECD guideline No. 420 [18].

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