Central Nervous System Related Studies on Andrographis paniculata Nees (Research Article)

Author(s): Vijay Danapur* and Y. N. Seetharam

Abstract: Plants, which include a multitude of medicinal substituent, have served us for millennia with their complex capacity to impede various etiologies. Plants have been exploited for their pharmacological application since ages but their use in the field of neuropharmacological activities are far less explored. Additionally, the questions regarding synthetic drug’s, safety on prolonged exercise, economic burden and the other deleterious side effects including the inevitable physical dependency have all paved the way to find an alternate natural treatment strategy. In the present study A. paniculata has been investigated to elucidate their influence on CNS by undergoing various tests. The test results revealed that, extracts of A. paniculata was not toxic up to 2000 mg/kg of the sample. Although, they did not produce sedative or anesthetic effect, but they hindered seizures thus securing their spot as an Anticonvulsant agent. Further, locomotor activity established it as a CNS depressant. All in all, A. paniculata had neuropharmacological activities which can be further explored.

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