An Integrated Review on Liposomes: A Potential Novel Drug Delivery System (Review Article)

Author(s): Riya Dhaigude, Pravin Kumar Sharma*, Sweta S Koka, Shraddha Mahajan, Anupam Mishra and G.N. Darwhekar

Abstract: Liposomes are a novel drug delivery (NDDS), which are vesicular constructions consisting of hydrated bilayers which form spontaneously when phospholipids are dispersed in water. They are used to deliver enzymes, proteins, and drugs to target cells or tissue (mostly cancer). Liposomes have been viewed as one of the most outstanding, versatile, flexible carrier systems, which provide an extensive chance for the delivery of multifarious drug molecules and applications. A liposome carrier can overcome the limitation and drawbacks of conventional therapies. Due to new traits in liposome technology, countless liposome-based drug formulations are presented in the clinical trial, and currently, some of them have been accepted for clinical use. Reformulation of drugs in liposomal form has provided the possibility to improve the therapeutic index of a variety of drugs and medicinal agents and in most cases through alteration in their in-vivo biodistribution.

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