Review on Chronopharmacology and Chronotherapeutics of Statins (Review Article)

Author(s): Naveen Poojar CM

Abstract: Chronopharmacology uses the knowledge of biological rhythms to develop an optimal pharmacotherapeutic plan. A self-evident physiological feature of living organisms is the fact that biological phenomena are not invariable over time, but manifest rhythmicity at the systemic, organ, and cellular level. Circadian rhythms can influence important functions in our bodies, such as Hormone release, Eating habits and digestion and Body temperature. Chronotherapeutics refers to a treatment method in which in vivo drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. The liver clock is largely responsible for buffering the circadian fluctuation of blood glucose and cholesterol in response to an individual’s eating habits. The conversion of cholesterol to mevalonate acid by HMGCoA reductase has been known to be circadian clock regulated. Studies found that atorvastatin showed no significant difference in lipid lowering effect between morning and evening administration whereas evening is the preferred time of administration for Simvastatin.

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