A Clinical Study on Health-Related Quality of Life Burden of Nonalcoholic Steatohepatitis

Author(s): P. Poli Reddy, A. Bheema Naik and K. N. V Rao

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat is stored in your liver. This buildup of fat is not caused by heavy alcohol use. Non-alcoholic fatty liver disease (NAFLD), also known as metabolic (dysfunction) associated fatty liver disease (MAFLD), is excessive fat build-up in the liver without another clear cause such as alcohol use. The aim of the study was to determine the quality of life and health utilities in patients with NAFLD with and without cirrhosis for future use. This is Descriptive Observational study. All the patients admitted in the department of General medicine and attending outpatient department of General medicine. Hyderabad during the period of January 2020 to August 2020, who are fitting into the inclusion criteria were included in the study. Patients with chronic liver disease for whom clinical and quality of life data had been collected for our quality-of-life database were considered for this study. We included only patients with an established histological diagnosis of NAFLD with or without cirrhosis who provided an informed consent; the presence of cirrhosis was determined from liver biopsies. Exclusion criteria included pregnant women, breast feeding. A total of 40 patients were enrolled as per inclusion and exclusion criteria, all together 38 patients were participated in this study, and the response was 100%. NASH is the second leading indication of CLD. this study clearly showed that compared to the general population, patients with NAFLD had significantly lower HRQL and health utility scores, which worsen with the advanced stages of the disease.

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