The Efficacy of Phytochemical Allicin on Non-Enzymic Antioxidants and Cytotoxicity Induction in Cultured Breast Cancer Cell Lines

Author(s): Anubha Chaudhari and Rajendra Chauhan

Abstract: The study aims at analyzing the efficacy of garlic derived phytochemical Allicin, in elevating the non-enzymic antioxidant activity and its cytotoxic potential on its treatment to cultured breast cancer cell lines. In the experiments, cultured breast cancer cell lines (MCF-7 and T47D) were treated with allicin and through standardized protocols the cell lines were assayed for the activities of non-enzymic antioxidants by way of analysis of Hydroxyl radical scavenging activity and Superoxide radical scavenging activity as compared to untreated control. Furthermore, cytotoxic potential of allicin was also analyzed by MTT assay. It was found that allicin treatment significantly increased the activity of the said non- enzymic antioxidant activities as compared to control. It was also found that allicin has a significant role in inducing cytotoxicity in the said cell lines and shows a promising growth inhibition potential. This study demonstrates that Allicin treatment to the said cancer cell lines shows a significant antioxidant activity and a significant cytotoxic potential which proposes future application of the phytochemical in cancer therapy in way which should be cost effective, easily available, and free from side effects of the synthetic anticancer drugs. The study also proposes future research in developing targeted delivery of such herbal chemicals to treat the dreaded disease.

PAGES: 129-138  |  158 VIEWS  297 DOWNLOADS