Preparation and Evaluation of Hydrodynamically Balanced Tablets Meloxicam (Research Article))

Author(s): Ch. Ajay Babu*, M. Prasada Rao and B. Anusha

Abstract: In the present study Gastroretentive delivery systems of Meloxicam were successfully developed in the form of Hydrodynamically Balanced Tablets to improve the local action and ultimately its bioavailability. The tablets were formulated using different grades of polymers (HPMC K4M, HPMC K15M and carbopol) and effervescing agent (NaHCO3).IR spectra studies revealed that the drug and the polymers used were compatible. The evaluation parameters like hardness, friability and content uniformity were within the limits for various batches formulated. Buoyancy lag time, Total floating time, tablet density, Swelling studies showed satisfactory results for batch F1, F2, F3, F5, F6 and F8. The formulation F3 was evaluated for effect of hardness on floating lag time, and the results showed that the floating lag time increased as hardness increased due to reduction in porosity. In vitro dissolution of batch F3 containing HPMC K15M showed good drug release rate in comparison to remaining batches containing carbopol HPMC K4M, HPMC K10M which were not able to sustain their release up to 10 hrs. Formulations subjected to curve fitting analysis showed to best fit Korsemeyer-Peppas equation and followed non-Fickinian diffusion mechanism. Comparison study with marketed product Meloxicam ER showed that the optimized formulation F3 has better control over release rate in comparison with the marketed product. Hence it was concluded that formulation F3 containing HPMC K15M showed better controlled drug release rate in comparison to other polymers and showed that the release decreases as the viscosity of the polymer increases.

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