Gallic Acid: A Review on Its Spectrum of Pharmacological Activities (Review Article)

Author(s): Sapna Desai, Jhanvi Sethi* and Hardi Shah

Abstract: The skin is the largest organ of the body and serves as a protective shield against the environmental stress like heat, light, injury and infection. On disclosure of the skin to this kind of variables in complement to chemical contaminants and additional mechanical elements can induce reactive oxygen species and the exhibition of free radicals. These are unstable radicals conjoined with further cellular components which leads to structural and cellular damage, which provoke a deployment in wound healing as well as rev the aging process. A wound is a disruption of normal anatomic structure and function which may result because of the mentioned factors. These wounds can be acute or chronic wounds. The skin has ability to repair such injuries as its essential for the survival but in some situations this potential to heal is disrupted as in cases of high glycemic patients. The healing of injury is a complex process and usually consists of 3 to 4 distinct phases which may be by a primary or a secondary union. Polyphenols, like gallic acid are an eminent category of antioxidants which shows a prominent effect in the series of wound healing. Gallic acid has high oxygen-derived free radical scavenging activity and has also been identified for curative effects like antimutagenicity, antiallergic, anti-inflammatory, anti-diabetic and anticarcinogenic activities. In this review we have focused on the importance of function of gallic acid in wound healing which is not only limited during normal but also hyperglycemic conditions where the healing process is affected.

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