Protective Role of Chrysoeriol, A Bioactive Flavonoid on Plasma and Tissue Glycoprotein Component Level Changes in Streptozotocin-Induced Hyperglycemic Rats (Research Article)

Author(s): *Baskaran. K, Nirmaladevi. N, Sumi.P and Jyothylakshmy Rajan

Abstract: The present study was conducted to investigate the effect of Chrysoeriol (CS) on dearrangement in glycoprotein levels in the streptozotocin (STZ) -induced diabetic model. Diabetes was induced in Male Wistar rats by a single intraperitoneal (i.p) injection of STZ (40 mg/kg B.W). The levels of glycoproteins were altered in experimental diabetes mellitus. The effects of CS on plasma glucose, insulin, plasma and tissue glycoproteins were studied. Oral administration of CS (20 mg/kg b.w) for 45 days positively modulates the glycemic status in STZ-induced diabetic rats. The levels of plasma glucose were significantly decreased and increased of plasma insulin level. The altered levels of plasma and tissue glycoprotein components were restored to near normal. The present findings suggest that CS can potentially ameliorate glycoprotein components abnormalities in addition to its antihyperglycemic effect in experimental diabetes. In light of these advantageous results, it is advisable to broaden the scale of use of CS in a trial to alleviate the adverse effects of diabetes.

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