Synthesis and Characterization of Lipoamino Acids Prepared from Aspartic Acid (Research Article)

Author(s): Akkaladevi Muralidhar Rao* and Gurusamy Mariappan

Abstract: We synthesized the derivatives of Aspartic acid ranging from alkyl chain length of C10 to C14 in excellent yields by a facile route. The method involves preparation of copper (II) complexes of Aspartic acid by regioselective coordination of amine and carboxylic groups which are in 1, 2 relationships. The acid functional group in diacidic amino acid is free which underwent further transformations such as salt formation by the use of N, N, N, N-Tetramethylguanidine and esterification by the treatment with suitable alkyl halide. The free β-esters of Aspartic Acid (A10, A12, A14) were isolated by precipitation and washing with acetone of the respective copper complexes and subsequent treatment with an excess of ethylene diamine tetra acetic acid acid (EDTA) disodium salt in water. Their structures have been elucidated by UV, IR, 1H NMR and mass spectra.

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