Antioxidant, Immunomodulatory and Anti-Cancer Activities of Sīr (Allium sativum L.) Bulb-Unani Medicine for Promotion of Healthy Ageing (Research Article)

Author(s): Shamim, Amanullah, Asim Ali Khan, Saad Ahmed and Lubna Fatima

Abstract: Sīr (garlic), species of the onion family, Liliaceae, is one of the most used plants in traditional medicine worldwide. More than 200 chemicals with diverse properties have been found in garlic extracts. Several garlic compounds were suggested to be efficient in improving various pathologies including certain types of cancer. It has Mu‘mmir (Longevity promoting agent), Muqawwī-i-Ḥarārat Gharīziyya (Tonic for Innate heat), Musakhkhin-i-Badan (Calorific) Muqawwī-i-Mi‘da (Stomachic), Muqawwī-i-Bāh (Aphrodisiac), Muḥallil-i-Waram (Anti-inflammatory), Qāti‘ Akhlāt-i-Ghalīza (Breaking agent for viscous humours), Muqarreḥ ( Ulcerative), Jālī (Detergent), Munaffith-i-Balgham (Expectorant),Musakkin (Analgesic), Mudirr-i-Bawl (Diuretic) etc. properties. It is used in Ḍu‘f-i-Ḥarārat Gharīziyya (Innate heat insufficiency), Amrāḍ-i-Bārida Balghamiyya (Cold phlegmatic disorders) such as Laqwa (Bell’s palsy), Istirkhā’ (Atony/flaccidity), Ri‘sha (Tremor) etc.,Fālij (Hemiplegia), Waja‘ al-Mafāṣil (Polyarthritis),‘Irq al-Nasā (Sciatica), Ḍīq al-Nafas (Bronchial Asthma), Su‘āl (Cough) Ḍu‘f-i-Bāh (Sexual debility), Amrāḍ-i- Jild (Skin Diseases like Bahaq (Pityriasis), Baraṣ (Vitiligo) etc. It showed Antioxidant, Immunomodulatory, Anti-ageing, Anti-Alzheimer’s Disease, Anti-cancer, Anti-viral, Anti-inflammatory, Antibacterial, Anti-fungal, Antiprotozoal, Anti-hyperlipidemic, Cardio protective, Antihypertensive, Anti-obesity, Anti-Atherosclerotic, Antithrombotic etc. activities.

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