Design, Synthesis and In Silico Studies of Some Novel Quinazoline Derivatives as Antimicrobial Agents (Research Article)

Author(s): O. Dhanya* and A. Aravind

Abstract: Quinazoline derivatives, which belong to the N-containing heterocyclic compounds, have triggered established issues due to their extensively and distinct biopharmaceutical sports. Quinazoline derivatives encompass a huge spectrum of pharmaceutical hobby profile inclusive of antitumor, anti-HIV, antimicrobial, antibacterial, anti-inflammatory, CNS activity and cardiovascular activity. The overall goal of this study has a look at ways to increase efficient artificial techniques for the synthesis of oxadiazole substituted quinazoline analogues. Based on in silico research, ten analogues have been taken for wet lab synthesis. The synthesized compounds were screened for antibacterial activity. The systems of the synthesized compounds were characterized by way of FT-IR, 1H NMR and MASS spectroscopy.

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