Study of Potential Biochemical Parameters in Patients Of Covid-19 (Research Article)

Author(s): Anupama Patne, P. J. Hisalkar, Virendra Goyal, and *Rekha Choudhary

Abstract: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is a respiratory disease, which can evolve into multiorgan failure (MOF), leading to death. Therefore, it makes sense to search for potential biomarkers that could rapidly and effectively identify severe cases early. Clinical samples from 100 cases of COVID-19 (25 severe cases, 37 mild cases and 38 moderate cases) was collected, enrolled from August 2020 in American International Institute of Medical sciences (AIIMS) & Hospital, Udaipur. We have evaluated the role of routine laboratory biomarkers and observed statistically significant abnormal values of biochemical and immunoassay parameters: C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), D-Dimer, Interleukin 6 (IL-6), Ferritin, Aspartate aminotransferase (AST) Alanine aminotransferase (ALT), Serum Albumin, Total Bilirubin (T Bil), and Creatinine in COVID 19 patients. Lymphopenia represents the hallmark of the disease, and it can be detected since the early stage of infection. Increased levels of several inflammatory biomarkers, including c- reactive protein, have been found in COVID-19 patients and associated with an increased risk of severe disease, which is characterized by “cytokine storm”. Also, the increase of cardiac and liver dysfunction biomarkers has been associated with poor outcome. Based on the findings of this study we may conclude that early detection of these parameters helps to reduce the severity of this disease.

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