Hepatoprotective Activity of Ethanolic Extract of Mukia maderaspatana Linn. M. Roem Against Paracetamol Induced Hepatotoxicity in Albino Rats (Research Article)

Author(s): Thiruppathi M*, Natarajan P, Abdul Rahman Basith M, Achara K, Arunkumar L and Abinesh S

Abstract: Introduction: Mukia maderaspatana (Family: Cucurbitaceae) is used to treat malarial fever and liver disorders. This study aims to investigate possible hepatoprotective activities of ethanolic extract of Mukia maderaspatana against paracetamol-induced hepatotoxicity. Methods: Hepatotoxicity was induced in Wistar albino rats by oral administration, 2 g/kg body weight on 7th day after the administration of ethanolic extract of Mukia maderaspatana and silymarin (100 mg/kg). Ethanolic extract of Mukia maderaspatana was administered orally at doses of 200 mg/kg and 400 mg/kg body weight daily for 7 days. Several serum enzyme markers, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin and total protein was measured to assess the effect of the extract on paracetamol (acetaminophen)-induced hepatic damage. The study included histopathological examination of liver sections. Results: Blood samples from rats treated with ethanolic extract of Mukia maderaspatana (200 mg/kg body weight and 400 mg/kg body weight) had significant reductions in serum markers in paracetamol administered rats, signifying the effect of the plant extract in restoring the normal functional ability of hepatocytes. Silymarin (100 mg/kg, p.o.) was used as a standard drug. Conclusion: The ethanolic extract of Mukia maderaspatana exhibits protective effects against paracetamol-induced hepatotoxicity.

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