Development of Glipizide-Loaded Floating Microspheres for Diabetes Treatment: Formulation, Characterization, and in-vivo Assessment (Research Article)

Author(s): Pritam Rajkumar Siraskar*, Dinesh Kumar Mishra and Sagar Naresh Firke

Abstract: Aim: The goal of the current study was to create glipizide floating microspheres that would maintain their stability for a longer period of time in the upper gastrointestinal tract (GIT), perhaps improving absorption and bioavailability. By employing polymers such hydroxyl propyl methyl cellulose (HPMC), ethyl cellulose in various ratios, and glipizide in each formulation. Method: The microspheres were made using the solvent evaporation process. The USP apparatus type I was used to carry out in vitro drug releases, and FTIR was used to determine the polymer compatibility of the microspheres. We investigated the yield, particle size, buoyancy percentage, drug entrapment efficiency, in vivo antidiabetic effectiveness of glipizide loaded microspheres, in vivo radiographic behavior, and in vitro drug release of the glipizide-laden microspheres. Result: The range of the yield of floating microspheres loaded with glipizide was determined to be 46.25±0.79% to 94.54±1.06%. The particle size ranged from 17.33 ±0.57 μm to 43.6±1.15 μm, with the maximum drug entrapment efficiency being 56.64 0.32 % and the buoyancy percentage being 90.33±0.91 %. With different formulations, the medication release characteristics changed.

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