A Systematic Review on Drug Repurposing (Review Article)

Author(s): Archana Chityala*, and Swarupa Arvapalli

Abstract: Drug repurposing is a process of identifying novel potential or new clinical use or therapeutic use for approved drug or existing drugs that are outside the scope of the original medical indication. Drug repurposing is also called Drug repositioning, drug redirecting and drug reprofiling. This has become a popular strategy in recent years. This strategy is highly efficient, time saving, low cost and minimum risk of failure. This strategy maximizes the therapeutic value of a drug and consequently increases the success rate. The development of New Chemical Entity (NCE) or New Molecular Entity (NME) is a very time-consuming process, complex, lengthy, and risky process. So, it is better to develop new drugs by applying drug repurposing strategy in drug discovery and development program. This drug repurposing involves three types of approaches: computational approaches, biological experimental approaches and mixed approaches which are used to develop or identify the new use of drug molecules on a rational basis. This drug repurposing is a powerful tool for the researchers for the development of new drug or identifying new therapeutic use for old/ existing drugs and banned drugs. During Covid-19, various investigators were carried out to design novel drug molecules by using different approaches of drug repurposing to identify drug substances for treatment of Covid-19,which can acts as significant inhibitor against viral proteins. The methodologies involved in drug repurposing can be categorized into three groups such as Drug oriented, Target oriented and Disease or therapy oriented. The challenges and opportunities in drug repurposing can be discussed from multiple perspectives, including technology, commercial models, patients and investments.

PAGES: 228-237  |  320 VIEWS  240 DOWNLOADS