Effect of Andrographolide on the Pharmacokinetics and Pharmacodynamics of Repaglinide in Diabetic Rats (Research Article)

Author(s): Prashanth Kumar Nandru, Baswaraju Macha, Narsimha Reddy Yellu*

Abstract: As aboriginal sources of medications, medicinal plants have been used since ancient times. Andrographis paniculata is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common colds, diarrhea, fever due to several infective causes, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents showed that repaglinide levels was increased in single dose and multidose treatment of repaglinide, may be due to metabolic inhibition of CYP3A4. It indicates that occurrence of drug interaction, which may be due to decreased metabolism of repaglinide. According to the results pharmacokinetics and pharmacodynamics of repaglinide are more pronounced in multi dose treatment groups of combination, it indicates the significance of long-term exposure of Andrographolide in diabetic condition, thus it may apply to diabetic patients under Repaglinide treatment. Hence, the combination has a beneficial effect in diabetic conditions, but special concern must be observed in diabetic patients in view of the side effects of Repaglinide.

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