Pulmonary Drug Delivery System: A Review

Author(s): Jukanti Harika Goud and Jimidi Bhaskar

Abstract: Growing attention has been given to the potential of pulmonary root as an alternative for noninvasive systemic delivery of therapeutic agents. Pulmonary drug delivery can be used as an alternative to oral delivery. The system can be best utilized for both local and systemic actions. Pulmonary Drug Delivery System (PDDS) is an important research area which impacts the treatment of illness including asthma, chronic obstructive pulmonary disease (COPD) and various other diseases. Inhalation gives the most direct access to the drug target. This route can be used to deposit the drug to the target site at the high concentration reducing the amount of drug given to the patient and help in reducing systemic side effects and first pass metabolism. Generally, half of all pharmaceuticals are not soluble in water, but are soluble in lipid. As the lungs can absorb both water and oil into the tissue this is not a restriction of pulmonary delivery.

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