Pharmacological Evaluation of Antidepressant and Antianxiety Activity of Desmostachya Bipinnata. (Research Article)

Author(s): Syed Ajaz Alam Qadri, Umesh T. Jadhao, Sayyed Asad Ali, Pradnya. D. Muneshwar and D. N. Male

Abstract: Anxiety and Depression are widespread psychiatric disorders affecting around 5% of the population. Furthermore, it is difficult to predict which patient will respond to any given treatment. In the traditional systems of medicine, many plants have been used to treat anxiety and depression for thousands of years. The present study was designed to evaluate the antianxiety and antidepressant activity of the alcoholic and aqueous extracts of Desmostachya Bipinnata leaves in rodents. Antianxiety activity was tested by exposing rats to unfamiliar aversion in different methods like elevated plus maze model and actophotometer. The results infer that reduced aversion fear elicits antianxiety activity. The antidepressant activity was tested by using forced swim test and Open Field Test. The results infer that reduced immobility time elicits antidepressant activity. It was concluded that alcoholic and aqueous extracts of Desmostachya Bipinnata leaves have antianxiety and antidepressant activity. Alcoholic extract of Desmostachya Bipinnata leaves showing more significant activity over the aqueous extract.

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