Impact of Ethanolic Extract of Ficus umbellata (Vahl.) Leaves On The Blood-Thinning Process In Wistar Rats Made Obese By A Hypercaloric Diet (Research Article)

Author(s): CHOKKI Steven.A.P.T.V, TCHOGOU Atchadé Pascal*, BEHANZIN Gbèssohèlè Justin, KONFO Tétédé Rodrigue Christian, SAVOEDA Perside, AGBOGBA Félicienne, AKPOLI Léocardie, BABA-MOUSSA Lamine, AHOKPE A. Mélanie, SENOU Maximin, SEZAN Alphonse

Abstract: Obesity is a factor favoring hypercoagulation of the blood and exposes the body to the risk of venous or arterial thrombosis, responsible for cardiovascular disease. The main aim of this study is to contribute to the prevention of thromboembolic diseases by evaluating the effect of ethanolic extract of Ficus umbellata (Vahl.) leaves on the blood-thinning process in obese Wistar rats. The in-vitro anticoagulant activity test revealed that in the presence of the plant extract at concentrations of 10, 30 and 50 mg/mL, no coagulation was observed when the coagulate was observed in the control tube. Hemostasis parameters (bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, fibrinogen, platelets and D-dimer) were determined in obese rats treated with different doses of the ethanolic extract of Ficus umbelleta leaves and aspirin® used as the reference molecule. The results revealed a dose-dependent prolongation of parameters such as bleeding time, Quick time, coagulation time, activated partial thromboplastin time and thrombin time for doses of 100, 300 and 500 mg/Kg body weight. The effect of the extract is similar to that of aspirin 100 mg. Ethanolic extract of Ficus umbelleta leaves and aspirin® liquefy blood by the same mechanism. Treated animals also showed an increase in fibrinogen levels, correlated with a reduction in platelet and D-dimer levels. The extract has been shown to inhibit platelet aggregation and slow blood coagulation

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