Safety of Covishield Vaccine After Prime and Booster Dose in Front Line Warriors of Warangal District (Research Article)

Author(s): A. Makarandh, Md. Nehaluddin, E. Venkateshwarlu and B.S. Sharavana bhava

Abstract: Background: The study is to assess the safety of COVISHIELD vaccine in front line warriors receiving prime and booster dose. Aim: The aim of this study is to evaluate safety of COVISHIELD vaccine. Methodology: A prospective observational study was conducted in vaccination centers in a tertiary care teaching hospital for a period of 6 months. All the front-line warriors who received prime and booster doses were included in the study and reviewed. Results: Overall all safety parameters were collected, out of which subjects with Hypertension are 16 (11%), Diabetes Mellitus 14 (9.60%), Fever 141 (97.10%), Injection Site pain 145 (100%), Rise in B.P 12 (8.20%), Headache 88 (60.60%), Nausea 38 (26.20%), Decreased appetite 28 (19.30%), Fatigue 68 (46.80%), Myalgia 65 (44.80%), Itching & Redness 18 (12.40%), Skin Rashes 16 (11%), Anosmia & Ageusia 2 (1.30%), Blurred Vision 7 (4.80%), Dry Lips 1 (0.60%),Giddiness 34 (23.40%), Cold& Cough 43 (29.60%), Eye Pain 2 (1.30%), Numbness 11 (7.50%), Increased Salivation 3 (2%), Mental Status Disturbance 2 (1.30%), Tachycardia 4 (2.70%), Leg Pain 10 (6.80%), Back Pain 17 (11.70%), Neck Pain 5 (3.40%), Ulcers in mouth 3 (2%), Tooth pain 1 (0.60%), Epigastric Pain 5 (3.40%), Hypotension 7 (4.80%), Swelling of knee 2 (1.30%), Facial puffiness 5 (3.40%), Weight gain 6 (4.10%), Blister Development 2 (1.30%). Conclusion: Our study demonstrates that the COVISHIELD vaccine is highly effective against the novel corona virus. The results of our study suggest that people who received both prime and booster doses have shown good efficacy to vaccine without any severe adverse drug reactions. It was concluded that adverse effects which appeared after the dose received are not very severe, can be relieved within two or three days. Overall, the safety of the COVISHIELD vaccine was decent. Further investigations are required to study the long-term efficacy of the vaccine and long-term adverse effects after two doses of vaccine.

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