Solid Dispersion-Method of Enhancement of Dissolution Rate and Increase Bioavailability (Review Article)

Author(s): Ayushi Jain*, Chanchal Jain, Pushpendra Gautam, Vinod Yadav, Anshika Bharti, Aanchal Yadav, Karan Singh, Arvind Ahirwar, Shreya Rajpoot, and Saraswati Kurmi

Abstract: To improve the dissolution of poorly water-soluble drugs and thus enhance their bioavailability, the dispersion of one or more active pharmaceutical ingredients in a carrier at solid-state is used. It has engrossed significant interest as an efficient means of improving the dissolution rate. It happens due to the dispersions of poorly water-soluble drugs with water-soluble carriers. One of the most challenging aspects in formulation development is solubility behavior of drugs. The number of poor water-soluble compounds has radically increased. Compared to conventional formulations such as tablets or capsules, solid dispersions prepared by various methods can be used which have many benefits over the above conventional dosage form. The focus of this review article is on the advantages, limitations, various methods of preparation and characterization of the solid dispersion. The different types of solid dispersions based on their molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization have also been discussed. In this review, it is intended to discuss the prospects related to the area of solid dispersion manufacturing.

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