EVALUATION OF EFFECT OF ICOFFEE BLACK (SALCITAL-PLUS) ON BIOAVAILABILITY OF METFORMIN HYDROCHLORIDE IN STREPTOZOTOCIN INDUCED RATS BY RP-HPLC METHOD

Author(s): G. Nagaraju*, V. Sirisha, Kavati.Ramakrishna and Hareesh Dara1

Abstract: Diabetes Mellitus (DM), DM is a serious metabolic disease that has a significant impact on the health, quality of life and life expectancy of patients, as well as on the health care system Metformin Hydrochloride is a first line drug for DM but has moderate bioavailability (50-60%). It is BCS class III drug, having high solubility and low permeability through intestinal mucosa, so it is necessary to increase the permeability of the drug and thus bioavailability. Enhancing Metformin hydrochloride absorption by oral ingestion is the most convenient and commonly used route of drug delivery. i-Coffee is a poly-herbal product for DM, having instant and high solubility in water. Thus, in continuation to our studies on the enhancement of bioavailability of Metformin hydrochloride using herbal products, herein we felt it worthwhile to study the impact of iCoffee on Metformin hydrochloride as they are widely consumed by the people in various districts of Telangana and other states of India.

PAGES: 875-884  |  202 VIEWS  227 DOWNLOADS