A Prospective and Comparative Study of Hemodialysis, Hemodiafiltration and Renal Transplant by Measurement of Quality of Life in Chronic Kidney Disease Patients (Research Article)

Author(s): Sneha Chittari, Asha Jyothi Vadlapudi*, Suma Vengala, Himaja Battu, Ranganath J. AL

Abstract: Background: Chronic Kidney Disease (CKD) is defined as malfunction of kidney structure in the last 3 months or more than 3 months. There are more than 850 million people suffering with kidney disease, which is increasing annually. In worldwide, 422 million peoples are suffering from diabetes, 42 million people develops the cancer in CKD patients 36.7 million people who are living with AIDS/HIV. The aim of the study is to measure the QOL in CKD patients on different treatment modalities of renal replacement therapy. For end stage renal disease (ESRD) the treatment modalities are Hemodialysis (HD), Hemodiafiltration (HDF) & Renal Transplant. Materials & methods: A prospective and comparative study on different treatment modalities of ESRD on single centered study was conducted in a tertiary care hospital, Hyderabad, for a duration of 10 months. In which 55 patients were screened, 30 patients were HD, 15 patients were HDF & 10 patients were Renal Transplant. The study patients were aged 21-80 years, most of the patients were co-diagnoses of Hypertension (HTN) & Diabetes millitus (DM). Results: The “SF-36 Questionnaire” which measures health status of and HD & HDF patients such as physical function, physical role limitations, bodily pain, general health perception, energy/vitality, social functioning, Emotional role limitations and mental health status interfere in the kidney disease patient is better in HDF patients than the HD patients. The clinical parameters such as sr. creatinine, blood urea nitrogen, sodium, potassium, chloride, hemoglobin, RBC & WBC are better in “Renal Transplant patients” than the “HDF patients” than the “HD patients”. The LVEF is superior in “Renal Transplant patients” than the “HDF patients” than the “HD patients” at the end of the study. Conclusion: When considering the different treatment modalities of CKD, HDF is the most effective treatment than HD. The renal transplant is superior to HDF.

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