Comparative In-Vitro Study of Generic Versus Brand Paracetamol Products (Research Article)

Author(s): Varsharani Mohite Managuli, Pallavi Gavhane Borge, Atmanand Kisan Sarode

Abstract: The use of brand-name versus generic drugs remains a contentious issue. The negative effects of non- equivalence result from either too little or too much drug reaching the patient, resulting in either treatment failure or adverse drug reactions. On the other hand, if physicians prescribe higher-priced original drugs to their patients instead of therapeutically equivalent lower-cost generic drugs, the patients must bear the additional cost. The purpose of this study was to compare the bioavailability of paracetamol in a generic versus branded formulation. The purpose of this study was to compare the bioavailability and pharmacokinetic behaviour of two branded formulations of aceclofenac. Weight variation, hardness, friability, disintegration, and dissolution were all tested for compliance with the United States Pharmacopoeia (USP) standards.

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