Polymeric In Situ Gel for Ophthalmic Drug Delivery: An Insight (Review Article)

Author(s): Mahua Bera*, Suman Pattanayak, Lakshikanta Kanthal1, Pritish Kumar Panda1, Bipratip Santra1, Rohit Maity, Sudip Bhowmik, and Indrajit Maity

Abstract: Ophthalmic drug delivery is recently an emerging approach as the eye is one of the utmost sensitive organs of the body. The prime challenges to the researcher to develop an effective ophthalmic drug delivery is not easy because of its administration route complexity such as impermeability of drugs to cornea, drainage, non-productive absorption, induced lacrimation and tear turnover, etc. There are various approaches for ophthalmic delivery but the ‘in situ gel’ system has appeared to be one of the best innovative drug delivery systems. The system is unique due to its inherent characteristics feature of sol-to-gel transition. Moreover, it is easy to prepare, easy to use, improves adherence, and also provides patient compliance by minimizing drug administration frequency. The in situ gels are one type of hydrogels that are the solution in form and undergo gelation in contact with body fluids or change in PH. Recently, it has been revealed that the in-situ gelling system are prepared by using various polymers such as PLGA, chitosan, guar gum, gellan gum, xanthan gum, carrageenan, xyloglucan, pectin etc. for ophthalmic delivery. This review mainly focused on the recent approaches of various polymeric in situ gel for ophthalmic drug delivery.

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