Pharmaceutical Cocrystals: Bridging Crystal Engineering and Drug Delivery for Improved Bioavailability (Review Article)

Author(s): Akarapu Spandana1*, Deepika Nerella, Sandhya Kolekar, Bathula Naveen Kumar, Vaidhugula Vikram

Abstract: Pharmaceutical cocrystals represent a versatile and effective platform for addressing solubility and formulation challenges in drug development. Pharmaceutical cocrystals are gaining their importance by researchers due to the possibility of altering the physical, chemical and mechanical properties of API without affecting its pharmacological activity. In spite of much work being done in this area, it is still more exploring area because of many newer applications like stability, permeability, taste masking, compressibility, bulk density etc. In this review, cocrystals classification is identified and its types are discussed. Cocrystals are held together by non-covalent interactions such as hydrogen bonding, π–π stacking, and van der Waals forces. The designs for cocrystals formation including Cambridge Structural Database are also discussed. This collection may provide a guidance in developing a new cocrystal which can have a good commercial value in the pharmaceutical industry.

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